Data/hora: 20/05/2024 11:38:07

Provedor de dados: 	3	
País: 	Brazil	
Título: 	Analysing the antidepressant and drug efflux competence of Clitoria ternatea L. as P-glycoprotein inhibitor to facilitate blood brain barrier	
Autores: 	Margret, Arockiya Anita; Dhayabaran, Violet; Suvaithenamudhan, Suvaiarasan; Parthasarathy, Subbiah.	
Data: 	2019-12-06	
Ano: 	2019	
Palavras-chave: 	Mental health; Ayurvedic herb; Kaempferol 3-O-(2״ 6״-di-O-rhamnopyranosyl) glucopyranoside; Animal despair studies; Rhodamine transport assay; Molecular docking.	
Resumo: 	Clitoria ternatea L. is a vital ayurvedic herb featured with a wide spectrum of mental health benefits. The present study investigates the competence of the plant against depression and to inhibit the membrane efflux protein P-glycoprotein (P-gp) that can regulate and restrict drug permeation into the brain. Antidepressant competence of the aqueous plant extract was assessed by animal despair studies on depression induced female mice models. The P-glycoprotein inhibitory potential of active phytocompounds was evaluated by molecular docking assay and substantiated by a cell line study. The in vivo studies exhibited a significant difference in the immobility time thereby establishing antidepressant activity. The histopathological sections from cortex region of treated brain showed decreased degenerative changes. Ten imperative phytocompounds facilitated docking complexes against P-glycoprotein among which Kaempferol 3-O-(2״,6״-di-O-rhamnopyranosyl) glucopyranoside exhibited a finest docking score of -12.569 kcal mol-1. Conversely it was attested by the rhodamine transport assay that demonstrated the inhibitory potential to surpass blood brain barrier. The outcome of the study endorses the efficacy of Clitoria ternatea L. as an idyllic brain drug and facilitates brain permeability	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/46629

10.4025/actascibiolsci.v41i1.46629	
Editor: 	Universidade Estadual De Maringá	
Relação: 	http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/46629/751375149051	
Formato: 	application/pdf	
Fonte: 	Acta Scientiarum. Biological Sciences; Vol 41 (2019): Publicação contínua; e46629

Acta Scientiarum. Biological Sciences; v. 41 (2019): Publicação contínua; e46629

1807-863X

1679-9283	
Fonte: 	Copyright (c) 2019 Acta Scientiarum. Biological Sciences

https://creativecommons.org/licenses/by/4.0